The role of XPB/Ssl2 double-stranded DNA translocase processivity in transcription start-site scanning.
E. J. Tomko, O. Luyties, J. K. Rimel, C.-L. Tsai, J. O. Fuss, J. Fishburn, S. Hahn, S. E. Tsutakawa, D. J. Taatjes, E. A. Galburt
This study compares the dsDNA translocase activity of holo- and core-TFIIH complexes in yeast and humans, finding that human core-TFIIH lacks processive translocation, unlike yeast core-TFIIH which also lacks it but has reduced ATPase activity.
Journal of Molecular Biology · Jul 1, 2021Peer-reviewedBiochemistry