Author

C.-L. Tsai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M.-C. Hung· 2 shared A. B. Maitra· 1 shared A. D'Souza· 1 shared A. Topolska-Wos· 1 shared B.-F. Pan· 1 shared B.-Y. Huang· 1 shared C. R. Hunt· 1 shared C.-F. Hung· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

M.-C. Hung

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

J. Fu, J. Li, C.-F. Li, C.-L. Tsai, W. Yin, J. Hou, P. Chen, Y. Cao, Y. Kang, Y. Sun, X. Xia, K. Furukawa, Y. Lu, M. Wu, Q. Huang, , P. Chiao

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

bioRxiv · Jul 28, 2022Cancer Biology

Two Interaction Surfaces between XPA and RPA Organize the Preincision Complex in Nucleotide Excision Repair

M. Kim, H. S. Kim, A. D'Souza, K. Gallagher, E. Jeong, A. Topolska-Wos, K. Ogorodnik Le Meur, C.-L. Tsai, M.-S. Tsai, M. Kee, J. A. Tainer, J.-E. Yeo, W. J. Chazin, O. D. Scharer

The paper investigates two interaction surfaces between XPA and RPA in the preincision complex of nucleotide excision repair, showing their distinct roles in complex assembly and NER activity.

bioRxiv · Mar 1, 2022Biochemistry

HP1β Chromo Shadow Domain facilitates H2A ubiquitination for BRCA1 recruitment at DNA double-strand breaks

T. Pandita, V. K. Charaka, S. Chakraborty, C.-L. Tsai, X. Wang, R. Pandita, J. Taineer, C. R. Hunt

This study identifies HP1β's chromo shadow domain as essential for promoting H2A ubiquitination and BRCA1 recruitment at DNA double-strand breaks to facilitate homologous recombination repair.

bioRxiv · Jan 11, 2022 · PreprintCell Biology

The role of XPB/Ssl2 double-stranded DNA translocase processivity in transcription start-site scanning.

E. J. Tomko, O. Luyties, J. K. Rimel, C.-L. Tsai, J. O. Fuss, J. Fishburn, S. Hahn, S. E. Tsutakawa, D. J. Taatjes, E. A. Galburt

This study compares the dsDNA translocase activity of holo- and core-TFIIH complexes in yeast and humans, finding that human core-TFIIH lacks processive translocation, unlike yeast core-TFIIH which also lacks it but has reduced ATPase activity.

Journal of Molecular Biology · Jul 1, 2021Peer-reviewedBiochemistry

Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 main protease by tafenoquine in vitro

Y. Chen, W.-H. Yang, L.-M. Huang, Y.-C. Wang, C.-S. Yang, Y.-L. Liu, M.-H. Hou, C.-L. Tsai, Y.-Z. Chou, B.-Y. Huang, C.-F. Hung, Y.-L. Hung, J.-S. Chen, Y.-P. Chiang, D.-Y. Cho, , M.-C. Hung

This study identifies tafenoquine as an inhibitor of SARS-CoV-2 main protease, showing it reduces protease activity and inhibits viral infection in vitro.

bioRxiv · Aug 14, 2020 · PreprintBiochemistry