D. J. Taatjes

Marker-based CRISPR screening reveals a MED12-p63 interaction that activates basal identity in pancreatic ductal adenocarcinoma

The paper identifies MED12-p63 interaction as a driver of basal identity in PDAC through genetic screens and biochemical analysis.

Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS-Mutant Cancers

This study shows that Mediator kinase inhibition prevents resistance to ERK/MAPK inhibitors in KRAS-mutant cancers by blocking transcriptional plasticity.

Possible Mechanism of Porosome-Mediated Exosome Release

The paper investigates porosome-mediated exosome release by knocking out SPCA1 in Min6 cells, showing reduced glucose-stimulated insulin and exosome release.

The role of XPB/Ssl2 double-stranded DNA translocase processivity in transcription start-site scanning.

This study compares the dsDNA translocase activity of holo- and core-TFIIH complexes in yeast and humans, finding that human core-TFIIH lacks processive translocation, unlike yeast core-TFIIH which also lacks it but has reduced ATPase activity.

Cystic fibrosis transmembrane conductance regulator (CFTR) inhibition results in mucus accumulation in human airway epithelia Calu-3 cells: Experimental and Machine Learning Studies

This study uses electron microscopy and machine learning to show that CFTR inhibition reduces secretory vesicle swelling and mucin release in Calu-3 cells, leading to mucus accumulation.

Differential expansion microscopy

This paper introduces differential expansion microscopy (DiExM) to measure anisotropic expansion in biological specimens, revealing subcellular structural distortions during expansion.