The 20-hydroxyecdysone agonist, halofenozide, promotes anti-Plasmodium immunity in Anopheles gambiae via the ecdysone receptor
R. A. Reynolds, H. Kwon, T. L. Alves e Silva, J. Olivas, J. Vega-Rodriguez, R. C. Smith
This study shows that halofenozide, a 20-hydroxyecdysone agonist, reduces Plasmodium infection in Anopheles gambiae by activating the ecdysone receptor via ultraspiracle, without affecting cellular immunity or AMP production.
bioRxiv · Jun 19, 2020Microbiology