J. Vega-Rodriguez

Anopheles salivary apyrase regulates blood meal hemostasis and drives malaria parasite transmission

This study shows that Anopheles salivary apyrase promotes Plasmodium transmission by modulating hemostasis during blood feeding.

Single-cell transcriptomics to define Plasmodium falciparum stage-transition in the mosquito midgut

This study uses single-cell transcriptomics to analyze Plasmodium falciparum development in the mosquito midgut, identifying transcriptional trajectories and stress responses, including genes encoding intrinsically disordered proteins.

Combining transgenesis with paratransgenesis to fight malaria

This study compares transgenesis and paratransgenesis for malaria control and finds that combining both strategies significantly enhances the inhibition of parasite development in mosquitoes.

A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoes

The paper identifies a high-affinity human monoclonal antibody against Pfs230 that blocks oocyst formation in mosquitoes by targeting gamete surfaces.

The 20-hydroxyecdysone agonist, halofenozide, promotes anti-Plasmodium immunity in Anopheles gambiae via the ecdysone receptor

This study shows that halofenozide, a 20-hydroxyecdysone agonist, reduces Plasmodium infection in Anopheles gambiae by activating the ecdysone receptor via ultraspiracle, without affecting cellular immunity or AMP production.

Generation of Transgenic Human Malaria Parasites With Strong Fluorescence in the Transmission Stages

The paper generates transgenic Plasmodium falciparum parasites with fluorescent transmission stages for improved study and screening.