Author

J. Orsel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. van de Ven· 2 shared M. L. den Boer· 2 shared M. W. E. Smeets· 2 shared A. Boeree· 1 shared C. E. J. Reichert· 1 shared C. H. J. Veltman· 1 shared E. M. P. Steeghs· 1 shared F. Stalpers· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

C. van de Ven

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2 papers

Recent·Most cited

Various Cell Types in the Bone Marrow sustain Primary B-Cell Precursor Acute Lymphoblastic Leukemia

M. W. E. Smeets, C. van de Ven, J. Orsel, C. E. J. Reichert, A. Boeree, J. M. Boer, M. L. den Boer

This study shows that BCP-ALL cells rely on supportive bone marrow cells for survival, with varying degrees of dependence across subtypes and through direct cell-cell contact.

bioRxiv · May 25, 2023 · PreprintCancer Biology

B-Cell Precursor Acute Lymphoblastic Leukemia elicits an Interferon-α/β response in Bone Marrow-derived Mesenchymal Stroma.

M. W. E. Smeets, E. M. P. Steeghs, J. Orsel, F. Stalpers, M. M. P. Vermeeren, C. H. J. Veltman, S. Nierkens, C. van de Ven, M. L. den Boer

This study shows BCP-ALL cells induce an IFN-α/β gene signature in MSCs via tunneling nanotubes, but this does not enhance leukemic cell survival or drug resistance.

bioRxiv · May 9, 2023Cancer Biology