Author

S. Nierkens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

A. M. Cornel· 2 shared J. Kuball· 2 shared M. Mokry· 2 shared A. A. K. Samat· 1 shared A. Boltjes· 1 shared A. Cutilli· 1 shared A. D. Meringa· 1 shared A. Hanash· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersImmunology

A. M. Cornel

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia

F. Barneh, J. B. Koedijk, N. E. Wijnen, T. Meulendijks, M. Ashtiani, E. Dunnebach, N. Dautzenberg, A. M. Cornel, A. Krippner-Heidenreich, K. Klein, C. M. Zwaan, J. Kuball, S. Nierkens, J. Cloos, G. J. L. Kaspers, O. Heidenreich

This study evaluates CD19 expression in pediatric AML and shows that CD19-directed immunotherapies are effective against CD19+ AML, similar to their efficacy in BCP-ALL.

bioRxiv · Apr 19, 2024Immunology

Engineering BCMA CAR T cells for myeloma-targeted cargo delivery

T. Kimman, M. Cuenca, A. Slomp, R. G. Tieland, D. Rockx-Brouwer, S. Heijhuurs, A. D. Meringa, W. Boschloo, D. M. Bosma, S. Kroos, V. lo Presti, S. Nierkens, N. Bovenschen, J. Kuball, M. C. Minnema, , V. Peperzak

This paper develops BCMA CAR T cells with a granzyme B-NOXA fusion to enhance apoptosis in multiple myeloma cells, improving killing efficacy in vitro and in xenograft models.

bioRxiv · Feb 14, 2024 · PreprintImmunology

B-Cell Precursor Acute Lymphoblastic Leukemia elicits an Interferon-α/β response in Bone Marrow-derived Mesenchymal Stroma.

M. W. E. Smeets, E. M. P. Steeghs, J. Orsel, F. Stalpers, M. M. P. Vermeeren, C. H. J. Veltman, S. Nierkens, C. van de Ven, M. L. den Boer

This study shows BCP-ALL cells induce an IFN-α/β gene signature in MSCs via tunneling nanotubes, but this does not enhance leukemic cell survival or drug resistance.

bioRxiv · May 9, 2023Cancer Biology

Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function

P. J. Coffer, C. A. Lindemans, A. Cutilli, S. A. Jansen, C. C. de Koning, M. van Hoesel, S. Nierkens, M. Mokry, E. E. Nieuwenhuis, E. Mocholi, A. Hanash

This study shows chemotherapy-induced intestinal damage promotes T cell activation and trafficking via galectin-9, linking epithelial injury to GVHD pathogenesis.

bioRxiv · Apr 30, 2023 · PreprintImmunology

Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

J. Wienke, L. L. Visser, W. M. Kholosy, K. M. Keller, M. Barisa, S. Munnings-Tomes, E. Carlton, E. Poon, A. Rodriguez, R. Bernardi, F. Van den Ham, S. R. Van Hooff, Y. A. H. Matser, M. Tas, K. P. S. Langenberg, , J. J Molenaar

The paper uses single-cell RNA sequencing to analyze neuroblastoma and identifies the NECTIN2-TIGIT axis as a potential target for immunotherapy.

bioRxiv · Jul 15, 2022Cancer Biology

Soluble signal inhibitory receptor on leukocytes-1 is released from activated neutrophils by proteinase 3 cleavage

H. J. von Richthofen, G. H. A. Westerlaken, D. Gollnast, S. Besteman, E. M. Delemarre, K. Rodenburg, P. Moerer, D. A. C. Stapels, A. K. Andiappan, O. Rotzschke, S. Nierkens, H. L. Leavis, L. J. Bont, S. H. M. Rooijakkers, L. Meyaard

The paper shows that activated neutrophils release soluble SIRL-1 via proteinase 3 cleavage, and that sSIRL-1 is present in vivo in RSV and COVID-19 patients.

bioRxiv · Mar 3, 2022Immunology

Functional Specialization of Specific DC Subsets in the Synovial Fluid of JIA Patients

A. Boltjes, A. A. K. Samat, M. Plantinga, M. Mokry, B. Castelijns, J. Swart, S. Vastert, M. Creyghton, S. Nierkens, J. van Loosdregt, F. van Wijk

This study identifies functional specialization of dendritic cell subsets in synovial fluid of JIA patients, showing cDC2 and monocytes are pro-inflammatory while cDC1 remains quiescent.

bioRxiv · Feb 9, 2022 · PreprintImmunology