Author

M. L. den Boer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

C. van de Ven· 2 shared J. M. Boer· 2 shared J. Orsel· 2 shared M. W. E. Smeets· 2 shared A. Attarbaschi· 1 shared A. Beishuizen· 1 shared A. Boeree· 1 shared B. Burkhardt· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

C. van de Ven

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Author profile →

3 papers

Recent·Most cited

Mutational and transcriptional landscape of pediatric B-cell precursor lymphoblastic lymphoma

E. Kroeze, I. Iaccarino, M. M. Kleisman, M. Mondal, T. Beder, M. Khouja, M. P. Hoeppner, M. Scheijde-Vermeulen, L. A. Kester, M. Brueggemann, C. D. Baldus, G. Cario, R. S. Bladergroen, N. Garnier, A. Attarbaschi, , W. Klapper

This study presents the first comprehensive mutational and transcriptional analysis of B-cell precursor lymphoblastic lymphoma (BCP-LBL), revealing molecular similarities to BCP-ALL but with distinct mutation patterns in epigenetic modifiers.

bioRxiv · Dec 27, 2023Cancer Biology

Various Cell Types in the Bone Marrow sustain Primary B-Cell Precursor Acute Lymphoblastic Leukemia

M. W. E. Smeets, C. van de Ven, J. Orsel, C. E. J. Reichert, A. Boeree, J. M. Boer, M. L. den Boer

This study shows that BCP-ALL cells rely on supportive bone marrow cells for survival, with varying degrees of dependence across subtypes and through direct cell-cell contact.

bioRxiv · May 25, 2023 · PreprintCancer Biology

B-Cell Precursor Acute Lymphoblastic Leukemia elicits an Interferon-α/β response in Bone Marrow-derived Mesenchymal Stroma.

M. W. E. Smeets, E. M. P. Steeghs, J. Orsel, F. Stalpers, M. M. P. Vermeeren, C. H. J. Veltman, S. Nierkens, C. van de Ven, M. L. den Boer

This study shows BCP-ALL cells induce an IFN-α/β gene signature in MSCs via tunneling nanotubes, but this does not enhance leukemic cell survival or drug resistance.

bioRxiv · May 9, 2023Cancer Biology