Disruption of oncogenic targeting by ISWI via phosphorylation of a prion-like domain
M. Chen, J. P. Foster, I. C. Lock, N. H. Leisenring, A. R. Daniel, W. Floyd, E. S. Xu, I. J. Davis, D. G. Kirsch
The paper shows that ionizing radiation disrupts oncogenic interactions between the fusion oncoprotein FUS-CHOP and the chromatin remodeler ISWI via phosphorylation of FUS-CHOP's prion-like domain, explaining radiation sensitivity in myxoid liposarcoma.
bioRxiv · Mar 11, 2020 · PreprintCancer Biology