Author

J. P. M. Coolen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

H. F. L. Wertheim· 2 shared W. J. G. Melchers· 2 shared A. Tostmann· 1 shared B. C. van der Putten· 1 shared C. P. Bleeker-Rovers· 1 shared C. Schultsz· 1 shared E. C. T. H. Tan· 1 shared E. den Drijver· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

H. F. L. Wertheim

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 17, 2023

The streptococcal phase-variable Type I Restriction-Modification system SsuCC20p dictates the methylome of Streptococcus suis and impacts virulence

T. Roodsant, B. C. van der Putten, J. Brizuela…·C. Schultsz

This paper shows that the phase-variable Type I RM system SsuCC20p in Streptococcus suis affects genome methylation, gene expression, and virulence through epigenetic regulation.

DOI 10.1101/2023.03.17.533248

mousezebrafish

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MicrobiologyMicrobial GenomicsPeer-reviewedApr 22, 2021

Genome-wide analysis in Escherichia coli unravels an unprecedented level of genetic homoplasy associated with cefotaxime resistance.

J. P. M. Coolen, E. den Drijver, J. J. Verweij…·M. A. Huynen

The paper identifies a −42 C>T mutation in the ampC promoter as significantly associated with cefotaxime resistance in E. coli through genome-wide homoplasy analysis.

DOI 10.1099/mgen.0.000556

E. coliwhole-genome sequencing

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MicrobiologybioRxivPreprintOct 29, 2020

Novel SARS-CoV-2 Whole-genome sequencing technique using Reverse Complement PCR enables easy, fast and accurate outbreak analysis in hospital and community settings

F. Wolters, J. P. M. Coolen, A. Tostmann…·W. J. G. Melchers

This paper introduces RC-PCR for SARS-CoV-2 whole-genome sequencing, demonstrating its accuracy and utility in outbreak analysis.

DOI 10.1101/2020.10.29.360578

humanwhole-genome sequencing

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