Author

H. F. L. Wertheim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

J. P. M. Coolen· 2 shared W. J. G. Melchers· 2 shared A. Fox· 1 shared A. Tostmann· 1 shared A. X. Han· 1 shared C. A. Russell· 1 shared C. P. Bleeker-Rovers· 1 shared D. Eggink· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

J. P. M. Coolen

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Author profile →

3 papers

Recent·Most cited

Genome-wide analysis in Escherichia coli unravels an unprecedented level of genetic homoplasy associated with cefotaxime resistance.

J. P. M. Coolen, E. den Drijver, J. J. Verweij, J. Schildkraut, K. Neveling, W. J. G. Melchers, E. Kolwijck, H. F. L. Wertheim, J. Kluytmans, M. A. Huynen

The paper identifies a −42 C>T mutation in the ampC promoter as significantly associated with cefotaxime resistance in E. coli through genome-wide homoplasy analysis.

Microbial Genomics · Apr 22, 2021Peer-reviewedMicrobiology

Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children

A. X. Han, Z. C. Felix Garza, M. R. A. Welkers, R. M. Vigeveno, N. D. Tran, T. Q. M. Le, Q. T. Pham, D. T. Dang, T. N. A. Tran, M. T. Ha, T. H. Nguyen, Q. T. Le, T. H. Le, T. B. N. Hoang, K. Chokephaibulkit, , C. A. Russell

This study examines within-host evolutionary dynamics of seasonal and pandemic influenza A viruses in young children, finding that nonsynonymous mutations decrease over time in A/H1N1pdm09 but increase in A/H3N2 due to mutation-selection balance.

bioRxiv · Mar 20, 2021Microbiology

Novel SARS-CoV-2 Whole-genome sequencing technique using Reverse Complement PCR enables easy, fast and accurate outbreak analysis in hospital and community settings

F. Wolters, J. P. M. Coolen, A. Tostmann, L. F. J. van Groningen, C. P. Bleeker-Rovers, E. C. T. H. Tan, N. van der Geest-Blankert, J. L. A. Hautvast, J. Hopman, H. F. L. Wertheim, J. C. Rahamat-Langendoen, M. Storch, W. J. G. Melchers

This paper introduces RC-PCR for SARS-CoV-2 whole-genome sequencing, demonstrating its accuracy and utility in outbreak analysis.

bioRxiv · Oct 29, 2020 · PreprintMicrobiology