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2 papers
Recent·Most cited
J. P. Matson, A. M. House, G. D. Grant, H. Wu, J. Perez, J. Cook
The paper shows that human cells re-entering the cell cycle from quiescence have impaired p53-dependent origin licensing and slow MCM loading, leading to underlicensed first S phases and increased replication stress sensitivity.
bioRxiv · Feb 22, 2019Cell Biology
J. P. Matson, R. Dumitru, P. Coryell, R. M. Baxley, W. Chen, K. Twaroski, B. R. Webber, J. Tolar, A.-K. Bielinsky, J. Purvis, J. G. Cook
This study shows that rapid DNA replication origin licensing in pluripotent stem cells maintains pluripotency by enabling fast MCM loading despite short G1 phases.
bioRxiv · Jul 17, 2017Cell Biology