Author

J. G. Cook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 8 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 6 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:development & morphogenesis· 3 Approach:microscopy & imaging analysis· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

J. C. Limas· 4 shared K. M. Kedziora· 4 shared B. L. Mouery· 3 shared J. E. Purvis· 3 shared C. D. Taylor· 2 shared C. L. Young· 2 shared D. Fleifel· 2 shared H. K. Sobon· 2 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersCell Biology

J. C. Limas

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Author profile →

9 papers

Recent·Most cited

Differential endothelial cell cycle status in postnatal retinal vessels revealed using a novel PIP-FUCCI reporter and zonation analysis

Z. Liu, N. Tanke, A. Neal, T. Yu, T. Branch, J. G. Cook, V. L. Bautch

The paper introduces a novel PIP-FUCCI reporter to study endothelial cell cycle stages in postnatal retinal vessels and identifies G2 stalling in tip cells.

bioRxiv · Jan 4, 2024Cell Biology

APC/C prevents non-canonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor-induced arrest

B. L. Mouery, E. M. Baker, C. A. Mills, L. E. Herring, D. Fleifel, J. G. Cook

This paper shows APC/C activity is essential to maintain CDK4/6 inhibitor-induced arrest by preventing premature S phase entry through degradation of cyclin A.

bioRxiv · Nov 9, 2023 · PreprintCell Biology

Endothelial cell flow-mediated quiescence is temporally regulated and utilizes the cell cycle inhibitor p27

N. Tanke, Z. Liu, M. T. Gore, P. Bougaran, M. B. Linares, A. Marvin, A. Sharma, M. Oatley, T. Yu, K. Quigley, S. Vest, J. G. Cook, V. L. Bautch

This study shows that endothelial cell quiescence under flow is temporally regulated and depends on p27, with arterial flow leading to deeper quiescence requiring HES1 and ID3.

bioRxiv · Jun 9, 2023Cell Biology

The molecular architecture of cell cycle arrest

W. Stallaert, S. R. Taylor, K. M. Kedziora, M. S. Johnson, C. D. Taylor, H. K. Sobon, C. L. Young, J. C. Limas, J. Varblow Holloway, J. G. Cook, J. E. Purvis

This study maps the molecular architecture of cell cycle arrest by analyzing 49 effectors, identifying stress-specific arrest states and mechanisms, and showing convergence onto a senescent state with a G1-like signature.

bioRxiv · Apr 27, 2022Cell Biology

Quantitative Profiling of Adaptation to Cyclin E Overproduction

J. C. Limas, A. N. Littlejohn, A. M. House, K. M. Kedziora, B. L. Mouery, B. Ma, D. Fleifel, A. Walens, M. M. Aleman, D. Dominguez, J. G. Cook

This study examines how mammalian cells adapt to chronic cyclin E overproduction, revealing that adaptation involves downregulation of G1-regulated genes and partial resistance to replication stress.

bioRxiv · Jul 26, 2021Cell Biology

The structure of the human cell cycle

W. Stallaert, K. M. Kedziora, C. D. Taylor, T. M. Zikry, H. K. Sobon, S. R. Taylor, C. L. Young, J. C. Limas, J. G. Cook, J. E. Purvis

The paper uses single-cell imaging and manifold learning to reveal alternative cell cycle paths and mechanisms of exit and re-entry in human cells.

bioRxiv · Feb 11, 2021Cell Biology

CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal

L. Crozier, R. Foy, B. L. Mouery, R. H. Whitaker, A. Corno, C. Spanos, T. Ly, J. G. Cook, A. T. Saurin

This study shows CDK4/6 inhibitors cause long-term cell cycle withdrawal by inducing replication stress and p53-dependent effects, linking them to genotoxic stress and potential combination therapies.

bioRxiv · Feb 3, 2021Cancer Biology

Precise detection of S phase onset reveals decoupled G1/S transition events

G. D. Grant, K. M. Kedziora, J. C. Limas, J. E. Purvis, J. G. Cook

The paper introduces PIP-FUCCI, a new reporter system for precise detection of S phase onset, revealing that APCCdh1 inactivation is not strictly required for S phase entry.

bioRxiv · Apr 12, 2018Cell Biology

Rapid DNA Replication Origin Licensing Protects Stem Cell Pluripotency

J. P. Matson, R. Dumitru, P. Coryell, R. M. Baxley, W. Chen, K. Twaroski, B. R. Webber, J. Tolar, A.-K. Bielinsky, J. Purvis, J. G. Cook

This study shows that rapid DNA replication origin licensing in pluripotent stem cells maintains pluripotency by enabling fast MCM loading despite short G1 phases.

bioRxiv · Jul 17, 2017Cell Biology