Author

J. P. Mochel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Assay:clinical cohort / trial· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

K. Allenspach· 3 shared A. Bourgois-Mochel· 2 shared B. Schneider· 2 shared A. Boyer· 1 shared A. E. Jergens· 1 shared A. Mosichuk· 1 shared B. Glanemann· 1 shared B. K. Schneider· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersCancer Biology

K. Allenspach

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Breakthrough: A First-In-Class Virtual Simulator for Dose Optimization of ACE Inhibitors in Veterinary Cardiology

B. K. Schneider, J. Ward, S. Sotillo, C. Garelli-Paar, E. Guillot, M. Prikazsky, J. P. Mochel

This study develops a virtual simulator for optimizing benazepril dosing in dogs with CHF using QSP modeling and provides a web-app for veterinary use.

bioRxiv · Nov 14, 2022 · PreprintPharmacology & Toxicology

CULTURE AND MAINTENANCE OF URINE-DERIVED, 3-DIMENSIONAL CANINE TRANSITIONAL CELL CARCINOMA ORGANOIDS

S. Thenuwara, B. Schneider, A. Mosichuk, V. Gabriel, C. Zdyrski, K. Dao, C. Iennarella-Servantez, M. Colosimo, D. Sahoo, A. Bourgois-Mochel, M. Musser, C. Johannes, J.-S. Palerme, K. Allenspach, J. P. Mochel

This study establishes urine-derived 3D canine TCC organoids as a model to study bladder cancer ex vivo, showing similar RNA biomarker expression and greater cisplatin sensitivity compared to 2D human TCC cells.

bioRxiv · Aug 24, 2021 · PreprintCancer Biology

Clinical Efficacy of Prebiotics and Glycosaminoglycans versus Placebo In Dogs with Food Responsive Enteropathy Receiving a Hydrolyzed Diet: A Pilot Study

K. Allenspach, B. Glanemann, Y.-J. Seo, S. L. Priestnall, O. A. Garden, L. Kilburn, M. Rossoni-Serao, S. Segarra, J. P. Mochel

This pilot study evaluates if prebiotics and glycosaminoglycans reduce relapse in dogs with food-responsive enteropathy on a hydrolyzed diet, finding no significant difference compared to placebo.

bioRxiv · Apr 13, 2021Immunology

Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer

B. Schneider, A. Boyer, J. Ciccolini, F. Barlesi, K. Wang, S. Benzekry, J. P. Mochel

The paper predicts optimal dosing gaps for BEV-PEM/CIS in mice and humans to maximize efficacy while minimizing toxicity.

bioRxiv · Feb 5, 2019Pharmacology & Toxicology

Adult Canine Intestinal Derived Organoids: A Novel In Vitro System for Translational Research in Comparative Gastroenterology

L. Chandra, D. C. Borcherding, D. Kingsbury, T. Atherly, Y. M. Ambrosini, A. Bourgois-Mochel, W. Yuan, M. Kimber, Y. Qi, Q. Wang, M. Wannemuehler, N. M. Ellinwood, E. Snella, M. Martin, M. Skala, , K. Allenspach

This paper develops a canine intestinal organoid system to study GI diseases in dogs and humans, showing it mimics in vivo tissue and supports functional assays.

bioRxiv · Nov 9, 2018 · PreprintCell Biology

Sacubitril/valsartan (LCZ696) Significantly Reduces Aldosterone and Increases cGMP Circulating Levels in a Canine Model of RAAS Activation

J. P. Mochel, C. H. Tang, M. Peyrou, J. Giraudel, M. Danhof, D. Rigel

This study shows sacubitril/valsartan increases cGMP and reduces aldosterone in a canine RAAS activation model compared to placebo and other drugs.

bioRxiv · Oct 5, 2018Pharmacology & Toxicology