W. Yuan

Selection constraints of plant adaptation can be relaxed by gene editing

This study shows that gene editing can relax selection constraints on plant traits by altering genetic correlations between flowering time and water use efficiency in Arabidopsis thaliana.

β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of femoral head

This study shows that β-catenin inhibition disrupts osteogenic/adipogenic differentiation in bone marrow mesenchymal cells, contributing to glucocorticoid-induced osteonecrosis of the femoral head.

The origin, divergence and inter-subspecies hybridization of house mice (Mus musculus)

This study traces the origin, divergence, and hybridization of three house mouse subspecies using population genomic data, revealing divergence times and patterns of introgression across Eurasia.

Induction of T-DNA amplification by retrotransposon-derived sequences

This study shows that retrotransposon-derived sequences in T-DNA can amplify transgene copy number in Arabidopsis, increasing targeted mutagenesis and gene targeting frequency.

N6-methyladenosine (m6A) and reader protein YTHDF2 enhance innate immune response by mediating DUSP1 mRNA degradation and activating mitogen-activated protein kinases during bacterial and viral infections

The paper shows that m6A and YTHDF2 regulate DUSP1 to enhance innate immune response during infections by promoting DUSP1 degradation and activating MAPKs.

Canalization of genome-wide transcriptional activity in Arabidopsis thaliana accessions by MET1-dependent CG methylation

This study shows that MET1-dependent CG methylation in Arabidopsis thaliana reduces epigenomic and transcriptomic diversity, canalizing gene expression while also increasing diversity for some genes.

Oxidative phosphorylation pathway disruption is an alternative pathological mechanism leading to Diamond-Blackfan anemia

This study identifies oxidative phosphorylation pathway disruption as an alternative mechanism causing Diamond-Blackfan anemia and shows coenzyme Q10 can rescue erythroid defects.

The asymmetric ABA response on both sides of root tip is important for tomato root hydrotropism by mediating proton efflux and cell elongation

This study shows that asymmetric ABA response in tomato root tips mediates proton efflux and cell elongation, driving hydrotropic bending toward water.

Rapid phenotypic differentiation and local adaptation in Japanese knotweed s.l. (Reynoutria japonica and R. x bohemica, Polygonaceae) invading novel habitats

This study examines phenotypic differentiation and local adaptation in Japanese knotweed clones across three habitats, finding mixed evidence for local adaptation despite low genetic diversity.

Metagenomics revealing molecular profiling of microbial community structure and metabolic capacity in Bamucuo, Tibet

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation

The paper develops a cell-adaptable hydrogel with stem cells to improve spinal cord injury repair by reducing neuroinflammation and enhancing axonal growth in rats.

Mechanism through which retrocyclin targets flavivirus multiplication

This study investigates how retrocyclin-101 inhibits flavivirus infection by targeting the NS2B-NS3 protease and the DE loop of the E glycoprotein.

Cryo-EM structures of human TMEM120A and TMEM120B

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

Phage-Derived Depolymerase as an Antibiotic Adjuvant Against Multidrug-Resistant Acinetobacter Baumannii

This paper identifies and characterizes a phage-derived depolymerase, Dpo71, which enhances antibiotic efficacy and immune response against multidrug-resistant Acinetobacter baumannii.

Structural and functional elucidation of NF-κB signaling by the p75 neurotrophin receptor through recruitment of TRADD

This study determines the structure of the p75NTR-DD/TRADD-DD complex and shows TRADD recruitment regulates NF-κB signaling and cell survival in cerebellar granule neurons.

A metabolic coincidence mechanism controls winter photoperiodism in plants

The paper identifies a metabolic coincidence mechanism in Arabidopsis that controls winter photoperiodism, independent of the canonical CO/FT pathway.

Adult Canine Intestinal Derived Organoids: A Novel In Vitro System for Translational Research in Comparative Gastroenterology

This paper develops a canine intestinal organoid system to study GI diseases in dogs and humans, showing it mimics in vivo tissue and supports functional assays.

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

The paper reports the crystal structure of LCAT bound to an activator and inhibitor, showing how the activator stabilizes the MBD and enhances LCAT activity in FLD variants.

Categorized analysis of forest ecological values in the China’s conversion cropland to forest program

The paper analyzes ecological benefit values of different forest restoration methods in China's CCFP program and finds water conservation has the highest value while nutrient accumulation is the lowest.