Author

J. R. Atack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

B. D. Bax· 2 shared C. R. Koulouris· 1 shared G. D. Fenn· 1 shared H. Waller-Evans· 1 shared J. A. Gillespie· 1 shared K. T. Elvers· 1 shared O. Grubisha· 1 shared R. A. Nicholls· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiophysics

B. D. Bax

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Author profile →

2 papers

Recent·Most cited

Tyrosine 121 moves revealing a druggable pocket that couples catalysis to ATP-binding in serine racemase

C. R. Koulouris, S. E. Gardiner, T. K. Harris, K. T. Elvers, S. M. Roe, J. A. Gillespie, S. E. Ward, O. Grubisha, R. A. Nicholls, J. R. Atack, B. D. Bax

The paper identifies a druggable pocket involving Tyr121 that couples catalysis to ATP-binding in serine racemase by analyzing structural changes in closed and open enzyme forms.

bioRxiv · Feb 12, 2021 · PreprintBiophysics

Crystallization and structure of ebselen bound to cysteine 141 of human inositol monophosphatase (IMPase).

G. D. Fenn, H. Waller-Evans, J. R. Atack, B. D. Bax

The paper presents the 1.47 Å crystal structure of human IMPase bound to ebselen, showing covalent attachment to Cys141 and tetramer formation through dimer interactions.

bioRxiv · Jul 8, 2020 · PreprintPharmacology & Toxicology