Author

K. T. Elvers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

B. D. Bax· 2 shared A. D. Davidson· 1 shared A. P. Beltrami· 1 shared C. R. Koulouris· 1 shared D. Arnold· 1 shared D. Hill· 1 shared E. Avolio· 1 shared F. Hamilton· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

B. D. Bax

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Author profile →

3 papers

Recent·Most cited

Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains

K. T. Elvers, M. Lipka-Lloyd, R. C. Trueman, B. D. Bax, Y. Mehellou

The paper determines the crystal structures of human SPAK and OSR1 CCT domains and measures their binding affinity to a WNK4 peptide, providing a basis for designing inhibitors targeting SPAK-activation.

bioRxiv · Aug 19, 2021Biochemistry

Tyrosine 121 moves revealing a druggable pocket that couples catalysis to ATP-binding in serine racemase

C. R. Koulouris, S. E. Gardiner, T. K. Harris, K. T. Elvers, S. M. Roe, J. A. Gillespie, S. E. Ward, O. Grubisha, R. A. Nicholls, J. R. Atack, B. D. Bax

The paper identifies a druggable pocket involving Tyr121 that couples catalysis to ATP-binding in serine racemase by analyzing structural changes in closed and open enzyme forms.

bioRxiv · Feb 12, 2021 · PreprintBiophysics

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

E. Avolio, M. Carrabba, R. Milligan, M. Kavanagh Williamson, A. P. Beltrami, K. Gupta, K. T. Elvers, M. Gamez, R. Foster, K. Gillespie, F. Hamilton, D. Arnold, I. Berger, M. Caputo, A. D. Davidson, , P. Madeddu

This paper shows that SARS-CoV-2 Spike protein causes cardiac pericyte dysfunction through CD147-mediated signaling, without infecting the cells.

bioRxiv · Dec 21, 2020Cell Biology