Author

S. M. Roe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2

Frequent Co-Authors

S. E. Ward· 2 shared A. W. Oliver· 1 shared B. D. Bax· 1 shared C. E. L. Fisher· 1 shared C. R. Koulouris· 1 shared F. M. G. Pearl· 1 shared G. Williams· 1 shared J. A. Gillespie· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

S. E. Ward

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Tyrosine 121 moves revealing a druggable pocket that couples catalysis to ATP-binding in serine racemase

C. R. Koulouris, S. E. Gardiner, T. K. Harris, K. T. Elvers, S. M. Roe, J. A. Gillespie, S. E. Ward, O. Grubisha, R. A. Nicholls, J. R. Atack, B. D. Bax

The paper identifies a druggable pocket involving Tyr121 that couples catalysis to ATP-binding in serine racemase by analyzing structural changes in closed and open enzyme forms.

bioRxiv · Feb 12, 2021 · PreprintBiophysics

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

X. Chen, Y. Ali, C. E. L. Fisher, R. Arribas-Bosacoma, M. B. Rajasekaran, G. Williams, S. Walker, J. R. Booth, J. J. R. Hudson, S. M. Roe, L. H. Pearl, S. E. Ward, F. M. G. Pearl, A. W. Oliver

The paper identifies an allosteric inhibitor of BLM's ATPase-coupled DNA helicase activity and characterizes its mechanism through crystallographic analysis.

bioRxiv · Nov 30, 2020Biochemistry