Cancer BiologybioRxivPreprint
PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix
E. J. Kay, K. Paterson, C. Riero Domingo…·S. Zanivan
This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.
DOI 10.1101/2020.05.30.125237