C. Jamieson

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

A first insight into the developability of an IgG3: A combined computational and experimental approach

This study characterizes the developability of IgG3 mAbs using computational and experimental methods, finding poorer stability and higher viscosity compared to IgG1.

E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled family members

This study shows RNF43 and ZNRF3 differentially regulate endocytosis of specific Frizzled family members through their transmembrane domains, linking these differences to cancer mutation patterns.

Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathway

This study shows that LKB1 loss in intestinal cells leads to a pre-malignant state linked to serrated colorectal cancer, which is amplified by loss-of-heterozygosity.

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.

Hypoxia-Induced PIM Kinase and Laminin-Activated Integrin α6 Mediate Resistance to PI3K Inhibitors in Bone-Metastatic CRPC

The paper identifies two survival pathways in bone-metastatic CRPC that confer resistance to PI3K inhibitors and shows combined inhibition of integrin α6β1 and PIM kinase is needed to overcome this resistance.