J. Riegger

Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by promoting the release of pro-anabolic mediators

Senolytic therapy with Dasatinib and Quercetin improves chondrocyte function in osteoarthritis by reducing senescence-associated secretory phenotype factors and increasing anabolic gene expression.

Increase of cell surface vimentin (CSV) is associated with vimentin network disruption and subsequent stress-induced premature senescence (SIPS) in human chondrocytes

This study shows that increased cell surface vimentin (CSV) in chondrocytes is linked to vimentin network disruption and stress-induced premature senescence, contributing to osteoarthritis progression.