Trans-endothelial insulin transport is impaired in skeletal muscle capillaries of obese male mice.
I. M. Williams, P. M. McClatchey, D. P. Bracy, J. S. Bonner, F. A. Valenzuela, D. H. Wasserman
This study shows that diet-induced obesity in male mice impairs trans-endothelial insulin transport, reduces endothelial vesicle density, and leads to skeletal muscle insulin resistance despite maintained interstitial insulin delivery.
bioRxiv · Mar 21, 2019Physiology