Inflammation drives age-induced loss of tissue resident macrophages
K. Ade, J. S. Coronilla, D. Obino, T. Weinberger, C. Kaiser, S. Mella, C. Chen, L. Katsimpardi, C. Werts, P. Dardenne, Y. Lallemand, E. Gomez-Perdiguero
The paper shows that inflammation causes age-related loss of tissue-resident macrophages, which cannot be replaced by hematopoietic stem cell-derived cells, and that reducing inflammation prevents this loss and improves liver aging.
bioRxiv · Oct 2, 2022 · PreprintImmunology