Polyubiquitinated PCNA promotes alternative lengthening of telomeres by inducing break-induced replication
S. Kim, N. Kang, J. S. Ra, S. H. Park, K. Myung, K.-y. Lee
The paper shows polyubiquitinated PCNA promotes break-induced replication at telomeres and fragile sites by recruiting SLX4, leading to telomere damage and DNA synthesis.
bioRxiv · Jul 13, 2023 · PreprintCell Biology