S. H. Park

Lytic transglycosylase repertoire diversity enables daughter cell separation and antibiotic resistance in Escherichia coli under acidic stress

This study identifies MltE and MltC as critical lytic transglycosylases that enable Escherichia coli survival and antibiotic resistance under acidic stress by facilitating daughter cell separation and maintaining membrane integrity.

Chromatinization Modulates Topoisomerase II Processivity

This study shows that chromatin enhances topoisomerase II processivity under both high and low torsional stress, with topo II relaxing over 6000 DNA turns on plectonemic DNA.

14K Prolactin Derived 14-Mer Antiangiogenic Peptide Targets Bradykinin-/Nitric Oxide-cGMP-Dependent Angiogenesis

This study identifies a novel 14-mer antiangiogenic peptide derived from prolactin that inhibits bradykinin- and eNOS-dependent angiogenesis, showing synergistic effects with Avastin in a colon cancer model.

Differences in Oligomerization of the SARS-CoV-2 Envelope Protein, Poliovirus VP4, and HIV Vpu

The paper uses native mass spectrometry to analyze the oligomerization states of SARS-CoV-2 E protein, poliovirus VP4, and HIV Vpu, revealing differences in their assembly patterns.

Polyubiquitinated PCNA promotes alternative lengthening of telomeres by inducing break-induced replication

The paper shows polyubiquitinated PCNA promotes break-induced replication at telomeres and fragile sites by recruiting SLX4, leading to telomere damage and DNA synthesis.

Evolutionary spread of protein L-(iso)aspartyl O-methyltransferases guides the discovery of distinct isoaspartate-containing peptides, pimtides

The paper identifies a new RiPP subclass, pimtides, by analyzing the evolutionary spread of PIMT enzymes and their role in modifying precursor peptides.

Coordinated and distinct LD-transpeptidase-independent roles of peptidoglycan carboxypeptidases DacC and DacA in stress adaptation and cell shape maintenance

This study identifies distinct and coordinated roles of DacC and DacA in stress adaptation and cell shape maintenance in E. coli, independent of LD-transpeptidases and involving interactions with PBPs.

ECPAS/Ecm29-Mediated 26S Proteasome Disassembly Is an Adaptive Response to Glucose Starvation

This study shows that ECPAS-mediated 26S proteasome disassembly into 20S and 19S subcomplexes occurs during glucose starvation, enhancing proteolysis and cell survival.

Identifying Proteasome 26S Subunit, ATPase (PSMC) Family Genes as the Prognostic Indicators and Therapeutic Targets in Lung Adenocarcinoma

This study identifies PSMC family genes as prognostic indicators and therapeutic targets in lung adenocarcinoma through differential expression, methylation, mutation, and survival analysis.

Divergent LD-transpeptidase-independent effects of peptidoglycan carboxypeptidases on intrinsic ss-lactam and vancomycin resistance

This study shows that peptidoglycan carboxypeptidases in E. coli and B. subtilis affect vancomycin and β-lactam resistance independently of LD-transpeptidases, with deletion causing β-lactam sensitivity and vancomycin resistance.

Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance

This study characterizes the structure of the Mis18 complex and identifies structural determinants essential for its assembly and centromere maintenance.

Mutual Regulation between PFKP and VEGF Promotes Glioblastoma Tumor Growth

This study identifies a mutual regulatory loop between PFKP and VEGF that promotes glioblastoma growth through AKT-mediated signaling and glycolytic enhancement.

MLL1 Methyltransferase Activity is Regulated by Distinct Nucleosome Binding Modes

The paper determines the cryoEM structure of the MLL1 complex bound to a nucleosome and identifies two binding modes, one of which is catalytically inactive.

Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity

This study investigates the structure of SARS-CoV-2 E protein and its interactions with amilorides, finding that binding affinity correlates with antiviral activity and that residue Asn15 is critical for maintaining the binding site conformation.

Single-cell Transcriptome of Bronchoalveolar Lavage Fluid Reveals Dynamic Change of Macrophages During SARS-CoV-2 Infection in Ferrets

This study uses single-cell RNA sequencing to track macrophage dynamics in SARS-CoV-2-infected ferrets over time, revealing distinct subpopulations and functional changes.

Third-generation dual-source computed tomography of the abdomen: comparison of radiation dose and image quality of 80kVp and 80/150kVp with tin filter

This study compares 80 kVp and 80/Sn150 kVp CT in oncology patients, finding 80 kVp provides better image quality and lower radiation dose.

Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome

The paper reports the cryo-EM structure of the human MLL1 complex bound to the nucleosome, revealing how it interacts with histone H3K4 and promotes tri-methylation.

SMAD3 Determines Conventional versus Plasmacytoid Dendritic Cell Fates

This study identifies SMAD3 as a key regulator determining conventional DC versus plasmacytoid DC differentiation through distinct gene regulatory mechanisms.

Molecular model of the nuclear pore complex reveals a thermoreversible FG-network with distinct territories occupied by different FG motifs

The paper develops a molecular model of the nuclear pore complex's central transporter, revealing a thermoreversible FG-network with distinct territories for different FG motifs.

IFN-γ selectively suppresses a subset ofTLR4-activated genes and enhancers to potentiate M1-like macrophage polarization

The paper shows IFN-γ suppresses specific TLR4-activated genes and enhancers to enhance M1-like macrophage polarization.