Facile generation of biepitopic antibodies with intrinsic agonism for activating receptors in the tumor necrosis factor superfamily
H. S. Jhajj, J. S. Schardt, N. Khalasawi, E. L. Yao, T. S. Lwo, N.-Y. Kwon, R. L. O'Meara, A. A. Desai, P. M. Tessier
This paper describes a method to generate biepitopic antibodies that activate TNF receptors by combining single-chain antibodies with IgG light chains, enhancing agonist activity without animal immunization.
bioRxiv · Dec 11, 2023Bioengineering