A. A. Desai

In vivo Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies

This study develops HALA antibodies that adjust ADC delivery based on tumor HER2 expression, improving efficacy across varying expression levels in preclinical models.

Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

Facile generation of biepitopic antibodies with intrinsic agonism for activating receptors in the tumor necrosis factor superfamily

This paper describes a method to generate biepitopic antibodies that activate TNF receptors by combining single-chain antibodies with IgG light chains, enhancing agonist activity without animal immunization.

Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils

This paper describes a FACS method using quantum dots to isolate high-quality conformational antibodies against insoluble antigens like amyloid fibrils.

Apolipoprotein M attenuates anthracycline cardiotoxicity and lysosomal injury

This paper investigates the role of apolipoprotein M in anthracycline cardiotoxicity, finding that ApoM protects against cardiac dysfunction and lysosomal injury through the autophagy-lysosome pathway.