Impulse initiation in engrafted pluripotent stem cell-derived cardiomyocytes can stimulate the recipient heart.
T. Stuedemann, B. Schwarzova, T. Schneidewind, B. Geertz, C. von Bibra, M. Nehring, J. Roessinger, J. S. Wiegert, T. Eschenhagen, F. Weinberger
This study shows that transplanted cardiomyocytes can electrically couple to the host myocardium and stimulate the recipient heart, triggering ventricular arrhythmias.
bioRxiv · Nov 12, 2023Pharmacology & Toxicology