A novel mouse allele of the DNA/RNA helicase senataxin (Setxspcar3) causing meiotic arrest of spermatocytes and male infertility
Y. Fujiwara, K. Saito, F. Sun, E. Inoue, J. Schimenti, Y. Okada, M. A. Handel
This study identifies a new Setx allele causing male infertility and female subfertility in mice by disrupting meiosis and spermatogenesis through R-loop accumulation and DNA damage.
bioRxiv · Apr 12, 2023 · PreprintCell Biology