K. Saito

A Novel Method to Visualize Active Small GTPases Unveils Distinct Sites of Sar1 Activation During Collagen Secretion.

The paper introduces SAIYAN, a method to detect small GTPase activation, revealing Sar1 activation at ER exit sites and ERGIC during collagen secretion.

Paroxetine-induced transient apoptosis with delayed neurogenesis induces brain remodeling in developing zebrafish

This study shows that early paroxetine exposure in zebrafish embryos causes transient apoptosis, delayed neurogenesis, and brain remodeling linked to ASD-like social behavior impairments.

Lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli: differential and interactive effects on novelty-induced hyperlocomotion, blood cytokine levels and TRL4-related processes

This study compares the effects of Porphyromonas gingivalis and Escherichia coli lipopolysaccharides on mouse behavior, cytokine levels, and TLR4 signaling, finding differential impacts on locomotion and cytokine responses.

Developmental noise and phenotypic plasticity are correlated in Drosophila simulans

This study quantifies phenotypic plasticity and developmental noise in Drosophila simulans and finds a positive correlation between them, suggesting they contribute to evolvability.

Absence of electron transfer-associated changes in the time-dependent X-ray free-electron laser structures of the photosynthetic reaction center

The paper investigates time-dependent structural changes in the photosynthetic reaction center using XFEL data and finds no clear link between structural changes and electron transfer events.

Characterization of Tryptophan Oxidation Affecting D1 Degradation by FtsH in the Photosystem II Quality Control of Chloroplasts

This study shows that Trp oxidation at the N-terminus of D1 protein enhances FtsH-mediated degradation during high-light stress in PSII repair.

A novel mouse allele of the DNA/RNA helicase senataxin (Setxspcar3) causing meiotic arrest of spermatocytes and male infertility

This study identifies a new Setx allele causing male infertility and female subfertility in mice by disrupting meiosis and spermatogenesis through R-loop accumulation and DNA damage.

A jasmonate-responsive ERF transcription factor regulates steroidal glycoalkaloid biosynthesis genes in eggplant

This study shows that overexpressing SmJRE4 in eggplant increases SGA biosynthesis genes, and jasmonate induces SmJRE4 while ethylene reduces this effect.

Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice

This study identifies a novel long ERα isoform enriched in female reproductive tissues and shows its critical role in reproductive function in female mice.

Excretion of triacylglycerol as a matrix lipid facilitating apoplastic accumulation of a lipophilic metabolite shikonin.

The paper investigates how plants secrete lipophilic metabolites like shikonin by excreting triacylglycerol as a matrix lipid, facilitating apoplastic accumulation.

Dynamic product-precursor relationships underlie cuticular lipid accumulation on maize silks

The study identifies how precursor chain length, plant genotype, and spatio-temporal gradients influence product-precursor ratios in the cuticular hydrocarbon-producing pathway of maize silks.

POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos

The paper introduces POLArIS, a probe for molecular orientation imaging, and demonstrates its use in visualizing actin filaments associated with microtubule asters in early embryos.

Tandem mass spectrum similarity-based network analysis using 13C-labeled and non-labeled metabolome data to identify the biosynthesis pathway of the blood pressure-lowering asparagus metabolite asparaptine A

The paper identifies the biosynthesis pathway of asparaptine A using metabolome network analysis and shows its blood pressure-lowering effects in mice.

Spatial metabolomics using imaging mass spectrometry to identify the localization of asparaptine in Asparagus officinalis

The paper uses spatial metabolomics to locate asparaptine in asparagus spears, showing its accumulation in lateral shoots and validating findings with LC-MS/MS.

Multi-metabolomics using imaging mass spectrometry and liquid chromatography-tandem mass spectrometry for spatially characterizing monoterpene indole alkaloids secreted from roots

The paper uses imaging mass spectrometry and LC-MS/MS to spatially characterize monoterpene indole alkaloids released from plant roots in agar.

Asymbiotic mass production of the arbuscular mycorrhizal fungus Rhizophagus clarus

This study shows that combining strigolactone and methyl jasmonate with myristate and organic nitrogen in asymbiotic cultures of Rhizophagus clarus HR1 increases spore production and infectivity, supporting plant growth.

Comparative analysis of antigen-specific anti-SARS-CoV-2 antibody isotypes in COVID-19 patients

This study compares antigen-specific antibody isotypes in COVID-19 patients to assess their kinetics, sensitivity, specificity, and correlation with neutralizing activity.

Molecular basis for gating of cardiac ryanodine receptor: underlying mechanisms for gain- and loss-of function mutations

This study identifies two gating mechanisms of RyR2 and shows how mutations affect channel function.

Canopy micrometeorology monitoring in diverse climates innovatively improves the evaluation heat-induced sterility of rice under climate change

This study evaluates heat-induced sterility in rice using canopy micrometeorology data across diverse climates, showing that panicle temperature can accurately predict sterility rates.

Myristate can be used as a carbon and energy source for the asymbiotic growth of arbuscular mycorrhizal fungi

This study shows that myristate supports asymbiotic growth of arbuscular mycorrhizal fungi by serving as a carbon and energy source.

Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan

The paper develops a poliovirus-nonsusceptible Vero cell line to support WHO's polio eradication efforts by reducing the risk of PV contamination in virus isolation.

In vivo deuterated water labeling allows tumor visualization via deuterium magnetic resonance spectroscopic imaging of cholesterol

Crystal structure of β-L-arabinobiosidase belonging to glycoside hydrolase family 121

The paper presents the crystal structure of β-L-arabinobiosidase (HypBA2) from Bifidobacterium longum, revealing its catalytic mechanism and conserved residues essential for substrate binding and catalysis.

Glycolytic metabolism of pathogenic T cells enables early detection of GvHD by 13C-MRI

This study uses 13C-MRI to detect early glycolytic activity in T cells, enabling non-invasive GvHD detection before symptoms appear.

Evaluation of the functional role of the maize Glossy2 and Glossy2-like genes in cuticular lipid deposition

Transgenic experiments show Gl2-like and Gl2 genes in maize have overlapping but divergent roles in cuticular lipid deposition, with Gl2-like requiring a catalytic motif for function.

Dual-localized enzymatic components that constitute the mitochondrial and plastidial fatty acid synthase systems

The paper identifies and characterizes three shared enzymes in mitochondrial and plastidial fatty acid synthase systems and shows their dual localization and functional consequences.

Mitotic ER exit site dissociation and reassembly is regulated by TANGO1 phosphorylation status

The paper shows that TANGO1 phosphorylation by CK1 during mitosis disrupts its interaction with Sec16, causing ER exit site dissociation, while a phosphatase PP1 regulates this process.

Basicity of N5 in semiquinone enhances the rate of respiratory electron outflow in Shewanella oneidensis MR-1

This study shows that the basicity of N5 in semiquinone cofactors enhances the rate of extracellular electron transport in Shewanella oneidensis MR-1 by facilitating protonation-dependent electron outflow.

LTK is an ER-resident receptor tyrosine kinase that regulates secretion

This study identifies LTK as an ER-resident receptor tyrosine kinase that regulates ER exit sites and ER-to-Golgi transport through interaction and phosphorylation of Sec12.

Distinguishing Closely Related Pancreatic Cancer Subtypes In Vivo by 13C Glucose MRI without Hyperpolarization

The paper distinguishes closely related pancreatic cancer subtypes in vivo using 13C glucose MRI without hyperpolarization by detecting metabolic differences through tensor decomposition.