Structure of the lysosomal membrane fusion machinery
D. Shvarev, J. Schoppe, C. Koenig, A. Perz, N. Fuellbrunn, S. Kiontke, L. Langemeyer, D. Januliene, K. Schnelle, D. Kuemmel, F. Froehlich, A. Moeller, C. Ungermann
This study determines the structure of HOPS, a lysosomal fusion machinery, revealing its rigid architecture and how it couples membrane tethering with SNARE assembly to facilitate fusion.
bioRxiv · May 5, 2022 · PreprintBiophysics