Regulatory sites in the Mon1-Ccz1 complex control Rab5 to Rab7 transition and endosome maturation
A.-C. Borchers, M. Janz, J.-H. Schaefer, A. Moeller, D. Kuemmel, A. Paululat, C. Ungermann, L. Langemeyer
bioRxiv · Mar 1, 2023Cell Biology
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D. Kuemmel
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
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2022-2023 · peak 2/yrCo-Author Collaboration Network
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Targeting of the Mon1-Ccz1 Rab guanine nucleotide exchange factor to distinct organelles by a synergistic protein and lipid code
E. Herrmann, L. Langemeyer, K. Auffarth, C. Ungermann, D. Kuemmel
The paper identifies a synergistic protein and lipid code that directs the Mon1-Ccz1 complex to distinct organelles, revealing how it differentially targets endosomes and autophagosomes.
bioRxiv · Aug 14, 2022Biochemistry
Structure of the lysosomal membrane fusion machinery
D. Shvarev, J. Schoppe, C. Koenig, A. Perz, N. Fuellbrunn, S. Kiontke, L. Langemeyer, D. Januliene, K. Schnelle, D. Kuemmel, F. Froehlich, A. Moeller, C. Ungermann
This study determines the structure of HOPS, a lysosomal fusion machinery, revealing its rigid architecture and how it couples membrane tethering with SNARE assembly to facilitate fusion.
bioRxiv · May 5, 2022 · PreprintBiophysics