Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation
E. Kalliara, M. Kardynska, J. Bagnall, D. G. Spiller, W. Müller, D. Ruckerl, S. K. Biswas, J. Smieja, P. Paszek
The paper shows that interferon stimulation induces long-term STAT1 desensitization through post-transcriptional feedback, enabling cells to remember past stimulation and adjust future responses.
bioRxiv · May 13, 2022Immunology