Author

D. G. Spiller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

P. Paszek· 5 shared J. Bagnall· 3 shared D. A. Jackson· 2 shared H. England· 2 shared J. Smieja· 2 shared M. Kardynska· 2 shared A. D. Adamson· 1 shared A. Paszek· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersCell Biology

P. Paszek

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Overexpression of IkappaBalpha modulates NF-kappaB activation of inflammatory target gene expression

P. Downton, J. S. Bagnall, H. England, D. G. Spiller, N. Humphreys, D. A. Jackson, P. Paszek, M. R. H. White, A. D. Adamson

This study shows that overexpression of IκBα reduces inflammatory gene expression by inhibiting p65 promoter binding, even when p65 dynamics remain intact.

bioRxiv · Mar 14, 2023Cell Biology

Single-cell imaging reveals non-cooperative and cooperative infection strategies of Listeria monocytogenes in macrophages

J. Moran, L. Feltham, J. Bagnall, M. C. Goldrick, E. A. Lord, C. Nettleton, D. G. Spiller, I. Roberts, P. Paszek

This study uses live-cell microscopy to show that L. monocytogenes infection of macrophages leads to heterogeneous outcomes, with non-cooperative bacterial behavior and population-level PrfA regulation affecting replication success.

bioRxiv · Jun 4, 2022 · PreprintMicrobiology

Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation

E. Kalliara, M. Kardynska, J. Bagnall, D. G. Spiller, W. Müller, D. Ruckerl, S. K. Biswas, J. Smieja, P. Paszek

The paper shows that interferon stimulation induces long-term STAT1 desensitization through post-transcriptional feedback, enabling cells to remember past stimulation and adjust future responses.

bioRxiv · May 13, 2022Immunology

Heat shock response pathways regulate stimulus-specificity and sensitivity of NF-κB signalling to temperature stress

A. Paszek, M. Kardynska, J. Bagnall, J. Smieja, D. G. Spiller, P. Widlak, M. Kimmel, W. Widlak, P. Paszek

The paper shows that heat shock response pathways modulate NF-κB signaling specificity and sensitivity to temperature stress in breast cancer cells.

bioRxiv · Sep 30, 2019 · PreprintCell Biology

Macrophage-specific NF-kappa B activation dynamics can segregate inflammatory bowel disease patients

S. Papoutsopoulou, M. D. Burkitt, F. Bergey, H. England, R. Hough, L. Schmidt, D. G. Spiller, M. H. White, P. Paszek, D. A. Jackson, V. A. Martins Dos Santos, G. Sellge, D. M. Pritchard, B. J. Campbell, W. Muller, C. Probert

This paper uses dynamic NF-kappaB activation assays in macrophages to stratify IBD patients into distinct phenotypic groups based on their response to stimulation.

bioRxiv · Jan 30, 2019Immunology