ICOS expression is required for maintenance but not the formation of germinal centers in the spleen in response to P. yoelii infection.
J. Stumhofer, K. A. O'Neal, L. E. Latham, E. Ntirandekura, C. L. Foscue
This study shows ICOS is needed to maintain germinal centers and Tfh cells during P. yoelii infection but not for their initial formation.
bioRxiv · Aug 24, 2021Immunology