J. C. Forrest

Intrinsic p53 Activation Restricts Gammaherpesvirus-Driven Germinal Center B Cell Expansion during Latency Establishment

This study shows that p53 activation restricts MHV68-driven GC B cell expansion during latency, with M2 and LMP1 triggering p53-dependent anti-proliferative responses.

Replication-dead gammaherpesvirus vaccine protects against acute replication, reactivation from latency, and lethal challenge in mice

This paper develops a replication-dead gammaherpesvirus vaccine that protects mice from acute replication, reactivation, and lethal disease caused by wild-type virus.

Uracil-DNA Glycosylase of Murine Gammaherpesvirus 68 Binds Cognate Viral Replication Factors Independently of its Catalytic Residues

This paper identifies a non-enzymatic role for murine gammaherpesvirus 68 vUNG in forming a complex with viral DNA replication factors, independent of its catalytic activity.

B cell-intrinsic STAT3-mediated support of latency and interferon suppression during murine gammaherpesvirus 68 infection revealed through an in vivo competition model

This study shows that B cell-intrinsic STAT3 supports gammaherpesvirus latency and suppresses interferon responses in mice, using a competitive infection model.

Lytic Replication and Reactivation from B cells Is Not Required for Maintaining Gammaherpesvirus Latency in vivo

This study shows that lytic replication and reactivation in B cells are not required for maintaining gammaherpesvirus latency in vivo, as latency was preserved despite ORF50 deletion.

Deletion of Murine Gammaherpesvirus Gene M2 in AID-Expressing B Cells Impairs Host Colonization and Viral Reactivation

This study deletes the M2 gene in AID-expressing B cells of MHV68 and shows it impairs viral reactivation and host colonization.

p53 Controls Murine Gammaherpesvirus Latency and Prevents Infection-Associated IgH/c- Myc Translocations

This study shows that p53 restricts MHV68 latency establishment and prevents infection-associated genomic instability in mice.