J. T. Gebert

Purinergic Signaling Drives Multiple Aspects of Rotavirus Pathophysiology

This study shows that blocking P2Y1 receptors reduces rotavirus-induced diarrhea and viral shedding in mice, suggesting P2Y1 signaling promotes disease.

Viroporin activity from rotavirus nonstructural protein 4 induces intercellular calcium waves that contribute to pathogenesis

This study identifies NSP4 as a viroporin that induces intercellular calcium waves, contributing to rotavirus virulence through innate immune activation and disease severity.

The Inositol Trisphosphate Receptor (IP3R) is Dispensable for Rotavirus-induced Ca2+ Signaling and Replication but Critical for Paracrine Ca2+ Signals that Prime Uninfected Cells for Rapid Virus Spread

This study shows that IP3R is dispensable for rotavirus replication in infected cells but critical for intercellular Ca2+ waves that prime uninfected cells for virus spread.