A. A. Philip

Viroporin activity from rotavirus nonstructural protein 4 induces intercellular calcium waves that contribute to pathogenesis

This study identifies NSP4 as a viroporin that induces intercellular calcium waves, contributing to rotavirus virulence through innate immune activation and disease severity.

Recombinant Rotavirus Expressing the Glycosylated S1 Protein of SARS-CoV-2

This study generates recombinant rotaviruses expressing full-length, glycosylated SARS-CoV-2 S1 protein, showing they can bind ACE2 and be recognized by anti-S1 antibodies.

Rotavirus NSP1 subverts the antiviral OAS-RNase L pathway by inducing RNase L degradation

This study identifies a novel mechanism by which rotavirus NSP1 subverts the OAS-RNase L antiviral pathway by inducing RNase L degradation through ubiquitination.

Generation of Recombinant Rotaviruses Expressing Human Norovirus Capsid Proteins

This paper generates recombinant rotaviruses expressing human norovirus capsid proteins and finds that shorter sequences are more genetically stable than longer ones.

Rotavirus as an Expression Platform of the SARS-CoV-2 Spike Protein

This paper demonstrates that recombinant rotaviruses can express SARS-CoV-2 spike protein domains, suggesting their potential as expression vectors for combined rotavirus-COVID-19 vaccines.

Expression of Separate Foreign Proteins from the Rotavirus NSP3 Genome Segment Using a Translational 2A Stop-Restart Element

This paper demonstrates that rotavirus can be engineered to express foreign proteins using a 2A stop-restart element, enabling the production of recombinant viruses with multiple fluorescent reporters.

Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum

This study characterizes dynamic calcium signaling during rotavirus infection, showing increased cytosolic calcium spikes and ER release, with NSP4 and SOCE playing key roles.