Author

J. M. Hyser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:imaging· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. L. Perry· 5 shared A. C. Strtak· 3 shared A. L. Chang-Graham· 3 shared M. K. Estes· 3 shared R. A. Britton· 3 shared C. Tomaro-Duchesneau· 2 shared H. A. Danhof· 2 shared J. Versalovic· 2 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersMicrobiology

J. L. Perry

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The Inositol Trisphosphate Receptor (IP3R) is Dispensable for Rotavirus-induced Ca2+ Signaling and Replication but Critical for Paracrine Ca2+ Signals that Prime Uninfected Cells for Rapid Virus Spread

J. L. Perry, F. J. Scribano, J. T. Gebert, K. A. Engevik, J. M. Ellis, J. M. Hyser

This study shows that IP3R is dispensable for rotavirus replication in infected cells but critical for intercellular Ca2+ waves that prime uninfected cells for virus spread.

bioRxiv · Aug 9, 2023 · PreprintMicrobiology

Rotavirus Induces Intercellular Calcium Waves Through ADP Signaling

A. C. Chang-Graham, J. L. Perry, M. A. Engevik, H. A. Danhof, F. Scribano, K. A. Engevik, J. Nelson, J. S. Kellen, A. C. Strtak, N. S. Palla, M. K. Estes, J. Versalovic, R. A. Britton, J. M. Hyser

This study shows rotavirus induces intercellular calcium waves via ADP signaling, which amplifies diarrheal symptoms and can be blocked by P2Y1 antagonists or knockout.

bioRxiv · Dec 31, 2019Microbiology

Generation of Recombinant Rotavirus Expressing NSP3-UnaG Fusion Protein by a Simplified Reverse Genetics System

A. Philip, J. L. Perry, H. Eaton, M. Shmulevitz, J. M. Hyser, J. Patton

This paper generates a recombinant rotavirus with a genetically modified segment 7 dsRNA encoding NSP3-UnaG fusion protein, showing efficient replication and enhanced detection compared to NSP1-based FPs.

bioRxiv · Oct 2, 2019Microbiology

Recovirus NS1-2 has viroporin activity that induces aberrant cellular calcium signaling to facilitate virus replication

A. C. Strtak, J. L. Perry, M. N. Sharp, A. L. Chang-Graham, T. Farkas, J. M. Hyser

This study identifies the NS1-2 protein of Tulane virus as a viroporin that disrupts calcium homeostasis, facilitating virus replication by altering cellular calcium signaling.

bioRxiv · Jul 16, 2019Microbiology

Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum

A. L. Chang-Graham, J. L. Perry, A. C. Strtak, N. K. Ramachandran, J. M. Criglar, A. A. Philip, J. T. Patton, M. K. Estes, J. M. Hyser

This study characterizes dynamic calcium signaling during rotavirus infection, showing increased cytosolic calcium spikes and ER release, with NSP4 and SOCE playing key roles.

bioRxiv · May 6, 2019Microbiology

Human intestinal enteroids with inducible neurogenin-3 expression as a novel model of gut hormone secretion

A. L. Chang-Graham, H. A. Danhof, M. A. Engevik, C. Tomaro-Duchesneau, U. C. Karandikar, M. K. Estes, J. Versalovic, R. A. Britton, J. M. Hyser

This paper develops a method to increase enteroendocrine cells in human intestinal enteroids using inducible neurogenin-3 expression, enabling functional studies of gut hormone secretion.

bioRxiv · Mar 16, 2019Microbiology

Discovery of a bacterial peptide as a modulator of GLP-1 and metabolic disease

C. Tomaro-Duchesneau, S. L. LeValley, D. Röth, L. Sun, F. T. Horrigan, M. Kalkum, J. M. Hyser, R. A. Britton

The paper identifies a bacterial peptide, GspA from Staphylococcus epidermidis, that stimulates GLP-1 secretion and reduces obesity and T2DM markers in mice.

bioRxiv · Jul 29, 2018Microbiology