Alpha-1 Antitrypsin Antisense Oligonucleotide Modulates Protease-Antiprotease Imbalance without Further Aggravating Smoke-induced Lung Injury
R. Xiao, K. Stearns, T. Zelonina, M. P. Goldklang, K. Blomenkamp, J. Teckman, J. M. D'Armiento
This study evaluates the safety of AAT ASO treatment in mice by assessing its impact on lung injury during smoke exposure and smoke-flu models, finding no significant worsening of lung damage.
bioRxiv · Jul 30, 2019 · PreprintPhysiology