R. Xiao

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.

Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis

The paper develops a standardized histopathologic evaluation approach for synovial membrane in murine OA models, showing good inter-reader agreement and consistent findings across stains.

Oxidative phosphorylation pathway disruption is an alternative pathological mechanism leading to Diamond-Blackfan anemia

This study identifies oxidative phosphorylation pathway disruption as an alternative mechanism causing Diamond-Blackfan anemia and shows coenzyme Q10 can rescue erythroid defects.

Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure

This study examines the effects of 33-ion galactic cosmic ray analog exposure on male mouse behavior and evaluates CDDO-EA as a potential countermeasure, finding no effect on exploration or anxiety but deficits in social novelty preference.

Crystal structure of the classical MHC-I molecule: insights into the MHC-I system in antiviral diseases in dogs

This study determines the crystal structure of pDLA-88*001:01 and identifies its peptide-binding motif, revealing structural differences between two categories of DLA-88 alleles in dogs and their implications for antiviral immunity.

YhcB (DUF1043), a novel cell division protein conserved across gamma-proteobacteria

This study characterizes YhcB, a conserved gamma-proteobacterial protein, showing it is essential for cell division and envelope integrity through genetic, structural, and interaction analyses.

Structural basis for the dimerization-dependent CRISPR-Cas12f nuclease

This study determines the cryo-EM structures of Cas12f to elucidate its dimerization-dependent mechanism for DNA cleavage and substrate recognition.

Thrombospondin-4 mediates hyperglycemia- and TGF-beta-induced inflammation in breast cancer

This study shows that thrombospondin-4 promotes inflammation and macrophage infiltration in breast cancer under hyperglycemia and TGF-beta conditions.

Alpha-1 Antitrypsin Antisense Oligonucleotide Modulates Protease-Antiprotease Imbalance without Further Aggravating Smoke-induced Lung Injury

This study evaluates the safety of AAT ASO treatment in mice by assessing its impact on lung injury during smoke exposure and smoke-flu models, finding no significant worsening of lung damage.