Host transcriptomic profiling of CD-1 outbred mice with severe clinical outcomes following infection with Orientia tsutsugamushi
J. Thiriot, Y. Liang, J. Fisher, D. H. Walker, L. Soong
This study uses CD-1 mice to model severe scrub typhus caused by Orientia tsutsugamushi, finding they exhibit high susceptibility and a Th1/CD8-skewed immune profile associated with disease severity.
bioRxiv · May 5, 2022Microbiology