Contribution of SARS-CoV-2 accessory proteins to viral pathogenicity in K18 hACE2 transgenic mice
J. Silvas, D. Morales Vasquez, J.-G. Park, K. Chiem, J. Torrelles, R. N. Platt, T. Anderson, C. Ye, L. Martinez-Sobrido
This study identifies ORF3a and ORF6 as key contributors to SARS-CoV-2 pathogenesis in mice using a reverse genetics system and K18 hACE2 transgenic mice.
bioRxiv · Mar 9, 2021Microbiology