Author

R. N. Platt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 4 Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

C. Ye· 4 shared J.-G. Park· 4 shared L. Martinez-Sobrido· 4 shared T. Anderson· 4 shared K. Chiem· 3 shared A. M. Emery· 2 shared B. L. Webster· 2 shared C. Hallam· 2 shared

Activity by Year

2017-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

C. Ye

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Genomic analysis of a parasite invasion: colonization of the Americas by the blood fluke, Schistosoma mansoni

R. N. Platt, W. Le Clec'h, F. D. Chevalier, M. McDew-White, P. LoVerde, R. Ramiro de Assis, G. Oliveira, S. Kinung'hi, A. G. Djirmay, M. L. Steinauer, A. Gouvras, M. Rabone, B. L. Webster, J. P. Webster, A. M. Emery, , T. J. Anderson

This study analyzes genomic data from Schistosoma mansoni to determine if there was a population bottleneck during its colonization of the Americas and identifies regions under selection.

bioRxiv · Oct 25, 2021Evolutionary Biology

The PIWI/piRNA response is relaxed in a rodent that lacks mobilizing transposable elements

M. W. Vandewege, R. N. Platt, D. K. Merriman, D. A. Ray, F. G. Hoffmann

The study examines PIWI/piRNA dynamics in 13-lined ground squirrels lacking mobilizing transposable elements, finding reduced PIWI expression and minimal TE transcriptional suppression.

bioRxiv · Jun 14, 2021Evolutionary Biology

Contribution of SARS-CoV-2 accessory proteins to viral pathogenicity in K18 hACE2 transgenic mice

J. Silvas, D. Morales Vasquez, J.-G. Park, K. Chiem, J. Torrelles, R. N. Platt, T. Anderson, C. Ye, L. Martinez-Sobrido

This study identifies ORF3a and ORF6 as key contributors to SARS-CoV-2 pathogenesis in mice using a reverse genetics system and K18 hACE2 transgenic mice.

bioRxiv · Mar 9, 2021Microbiology

Generation and Characterization of recombinant SARS-CoV-2 expressing reporter genes

K. Chiem, D. Morales Vasquez, J.-G. Park, R. N. Platt, T. Anderson, M. R. Walter, J. J. Kobie, C. Ye, L. Martinez-Sobrido

This paper generates and characterizes recombinant SARS-CoV-2 viruses expressing fluorescent or bioluminescent reporter genes, demonstrating their utility for tracking viral infection and screening therapeutics.

bioRxiv · Nov 16, 2020Microbiology

Rescue of SARS-CoV-2 from a single bacterial artificial chromosome

C. Ye, J.-G. Park, F. Oladunni, R. N. Platt, T. Anderson, F. Almazan, J. C. de la Torre, L. Martinez-Sobrido

The paper develops an infectious SARS-CoV-2 cDNA clone using a bacterial artificial chromosome, which replicates similarly to the natural virus in cell cultures and animal models.

bioRxiv · Jul 22, 2020Microbiology

Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice

F. Oladunni, J.-G. Park, P. Pino Tamayo, O. Gonzalez, A. Ahkter, A. Allue Guardia, A. Olmo-Fontanez, S. Gautam, A. Garcia Vilanova, C. Ye, K. Chiem, C. Headley, V. Dwivedi, L. Parodi, K. Alfson, , J. B. Torrelles

This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.

bioRxiv · Jul 18, 2020Microbiology

SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

D. K. Singh, S. R. Ganatra, B. Singh, J. Cole, K. J. Alfson, E. Clemmons, M. Gazi, O. Gonzalez, R. Escabedo, T.-H. Lee, A. Chatterjee, Y. Goez-Gazi, R. Sharan, R. Thippeshappa, M. Gough, , M

This study compares SARS-CoV-2 infection in three nonhuman primate species, showing varied disease progression and immune responses.

bioRxiv · Jun 5, 2020Immunology

Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites

R. N. Platt, M. McDew-White, W. Le Clec'h, F. D. Chevalier, F. Allan, A. M. Emery, A. Garba, A. Hamidou, S. M. Ame, J. P. Webster, D. Rollinson, B. L. Webster, T. J. C. Anderson

The paper identifies an ancient introgression event between Schistosoma haematobium and S. bovis, with adaptive selection on an invadolysin gene.

bioRxiv · Apr 22, 2019Evolutionary Biology

Conflicting evolutionary histories of the mitochondrial and nuclear genomes in New World Myotis

R. N. Platt, B. C. Faircloth, K. A. M. Sullivan, T. Kieran, T. C. Glenn, M. W. Vandewege, T. E. Lee, R. J. Baker, R. D. Stevens, D. A. Ray

The study examines conflicting evolutionary histories between mitochondrial and nuclear genomes in New World Myotis using UCE data and mitochondrial genomes.

bioRxiv · Jun 16, 2017Evolutionary Biology