Author

J. V. Layer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. J. Brown· 1 shared A. Van Scoyk· 1 shared B. D. Price· 1 shared D. M. Weinstock· 1 shared E. Karaca· 1 shared F. W. Alt· 1 shared F.-L. Meng· 1 shared H. Fuchs· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. J. Brown

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2 papers

Recent·Most cited

Site-specific targeting of a light activated dCas9-KIllerRed fusion protein generates transient, localized regions of oxidative DNA damage.

N. C. M. House, J. V. Layer, B. D. Price

This paper introduces dCas9-KR, a light-activated system that generates transient oxidative DNA damage, which is repaired via NHEJ without detectable mutations.

bioRxiv · Aug 4, 2020Cancer Biology

Parp3 promotes long-range end-joining in murine cells

J. V. Layer, J. P. Cleary, A. J. Brown, K. E. Stevenson, S. N. Morrow, A. Van Scoyk, R. B. Blasco, E. Karaca, F.-L. Meng, R. L. Frock, T. Tivey, S. S. Kim, H. Fuchs, R. Chiarle, F. W. Alt, , T. Day

This study shows Parp3 promotes chromosomal rearrangements in murine cells, contrasting with Parp1's suppressive role in DNA double-strand break processing.

bioRxiv · Jan 28, 2018Cancer Biology