T. Day

Variety is the spice of life: nongenetic variation in life histories influences population growth and evolvability

The paper examines how nongenetic variation in vital rates affects population growth and evolvability by modifying age-structured population models to include individual heterogeneity.

A stochastic analysis of the interplay between antibiotic dose, mode of action, and bacterial competition in the evolution of antibiotic resistance

This paper develops a stochastic model to analyze how antibiotic dose, mode of action, and bacterial competition influence resistance evolution, finding that resistance survival depends on density regulation and drug type.

Emergence and maintenance of stable coexistence during a long-term multicellular evolution experiment

This study shows how multicellularity evolves through niche partitioning and adaptive divergence in snowflake yeast, leading to stable coexistence via a trade-off between size and competitiveness for oxygen.

Parp3 promotes long-range end-joining in murine cells

This study shows Parp3 promotes chromosomal rearrangements in murine cells, contrasting with Parp1's suppressive role in DNA double-strand break processing.

qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps

qFit-ligand identifies unmodeled ligand conformations in crystal structures, revealing 29% of drug-like molecules exhibit conformational heterogeneity that could improve drug design.

Pathogen evolution: slow and steady spreads the best

The paper extends life history evolution theory to account for finite population size effects on pathogen virulence evolution, showing demographic stochasticity alters classical deterministic predictions.