Selective inhibition of CA IX over CA XII using benzene sulfonamides in breast cancer cells: Disconnect between CA activity and growth inhibition
M. Y. Mboge, Z. Chen, A. Wolff, J. V. Mathias, C. Tu, K. D. Brown, M. Bozdag, F. Carta, C. T. Supuran, R. McKenna, S. C. Frost
This study investigates the isoform-specific inhibition of CA IX and CA XII by benzene sulfonamides in breast cancer cells, finding greater specificity for CA IX and disconnect between CA activity and growth inhibition.
bioRxiv · Sep 18, 2018Cancer Biology