Author

S. C. Frost

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Y. Mboge· 3 shared A. Wolff· 2 shared C. J. Frost· 2 shared C. T. Supuran· 2 shared F. Carta· 2 shared K. D. Brown· 2 shared R. McKenna· 2 shared Z. Chen· 2 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

M. Y. Mboge

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3 papers

Recent·Most cited

β-Caryophyllene Enhances the Transcriptional Upregulation of Cholesterol Biosynthesis in Breast Cancer Cells

M. Y. Mboge, A. Ramirez-Mata, A. Bullock, R. O'Donnell, J. Mathias, J. Davila, C. J. Frost, S. C. Frost

This study shows that β-caryophyllene increases cholesterol and fatty acid synthesis in breast cancer cells, potentially as a response to its cytotoxic effects.

bioRxiv · Mar 6, 2019Cancer Biology

A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells

M. Y. Mboge, Z. Chen, D. Khokhar, A. Wolff, L. Ai, C. D. Heldermon, M. Boxdag, F. Carta, C. T. Supuran, K. D. Brown, R. McKenna, C. J. Frost, S. C. Frost

This study shows that carbonic anhydrase IX (CA IX) contributes to pH regulation and glycolytic phenotype in breast cancer cells through a non-catalytic function, independent of its enzymatic activity.

bioRxiv · Mar 5, 2019Cancer Biology

Selective inhibition of CA IX over CA XII using benzene sulfonamides in breast cancer cells: Disconnect between CA activity and growth inhibition

M. Y. Mboge, Z. Chen, A. Wolff, J. V. Mathias, C. Tu, K. D. Brown, M. Bozdag, F. Carta, C. T. Supuran, R. McKenna, S. C. Frost

This study investigates the isoform-specific inhibition of CA IX and CA XII by benzene sulfonamides in breast cancer cells, finding greater specificity for CA IX and disconnect between CA activity and growth inhibition.

bioRxiv · Sep 18, 2018Cancer Biology