R. McKenna

Structural characterization of antibody-responses from Zolgensma treatment provides the blueprint for the engineering of an AAV capsid suitable for redosing

This study uses cryo-EM to analyze antibodies against AAV9 vectors, identifying residues that enable capsid engineering to avoid neutralization and allow redosing.

Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection

This study improves cryo-EM data collection by reducing resolution attenuation during stage tilt, enabling isotropic map reconstruction of specimens with preferred orientations.

Structural and molecular biology of Acheta domesticus segmented densovirus, the first parvovirus to harbor a bipartite genome

Structures of LIG1 engaging with mutagenic mismatches inserted by polβ in base excision repair

This study determines the X-ray structures of LIG1 with mismatched DNA substrates to elucidate how LIG1 discriminates between mutagenic and correct mismatches during base excision repair.

Amino acid transporter B0AT1 influence on ADAM17 interactions with SARS-CoV-2 receptor ACE2 putatively expressed in intestine, kidney, and cardiomyocytes

This study investigates how B0AT1 influences ADAM17 interactions with ACE2 in intestinal, renal, and cardiomyocyte cells, revealing structural differences in ACE2 dimerization that may impact SARS-CoV-2 infection and immune responses.

CAIX forms a transport metabolon with monocarboxylate transporters in human breast cancer cells

The paper shows CAIX forms a complex with MCT1/4 in breast cancer cells, enhancing lactate transport and cell proliferation, and demonstrates disruption of this complex inhibits these processes.

A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells

This study shows that carbonic anhydrase IX (CA IX) contributes to pH regulation and glycolytic phenotype in breast cancer cells through a non-catalytic function, independent of its enzymatic activity.

Selective inhibition of CA IX over CA XII using benzene sulfonamides in breast cancer cells: Disconnect between CA activity and growth inhibition

This study investigates the isoform-specific inhibition of CA IX and CA XII by benzene sulfonamides in breast cancer cells, finding greater specificity for CA IX and disconnect between CA activity and growth inhibition.

Sub-2 A Ewald Curvature Corrected Single-Particle Cryo-EM

The paper improves cryo-EM resolution by correcting Ewald sphere curvature, achieving 1.86 Å resolution for an AAV2 variant.