GATA1-defective immune-megakaryocytes as possible drivers of idiopathic pulmonary fibrosis
F. Gobbo, M. Zingariello, P. Verachi, M. Falchi, F. Arciprete, F. Martelli, A. Peli, M. Mazzarini, J. Vierstra, C. Mead-Harvey, A. C. Dueck, G. Sarli, S. Nava, G. Sgalla, L. Richeldi, A. R. Migliaccio
The paper identifies GATA1-defective immune-megakaryocytes in IPF patients and mice, showing their role in lung fibrosis through TGF-β1, CXCL1, and P-selectin mechanisms.
bioRxiv · Jun 20, 2023 · PreprintImmunology